tailieunhanh - Báo cáo sinh học: "Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction networ"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. | J. Biol. Journal of Biology BioMed Central Research article Open Access Motifs themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang Oliver D King Sharyl L Wong Debra S Goldberg Amy HY Tong Guillaume Lesage Brenda Andrews Howard Bussey Charles Boone and Frederick P Roth Addresses Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA 02115 USA. Banting and Best Department of Medical Research and Department of Medical Genetics and Microbiology University of Toronto Toronto ON M5G 1L6 Canada. Department of Biology McGill University Montreal PQ H3A 1B1 Canada. Correspondence Frederick P Roth. E-mail fritz_roth@ Published 1 June 2005 Received 17 November 2004 Revised 21 February 2005 Journal of Biology 2005 4 6 J Igy Accepted 8 April 2005 The electronic version of this article is the complete one and can be found online at http content 4 2 6 2005 Zhang et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Large-scale studies have revealed networks of various biological interaction types such as protein-protein interaction genetic interaction transcriptional regulation sequence homology and expression correlation. Recurring patterns of interconnection or network motifs have revealed biological insights for networks containing either one or two types of interaction. Results To study more complex relationships involving multiple biological interaction types we assembled an integrated Saccharomyces cerevisiae network in which nodes represent genes or their protein products and differently colored links represent the aforementioned five biological interaction types. We examined three- and four-node .