tailieunhanh - Báo cáo y học: " Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. | Research Open Access Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites Tobias J Sargeant Matthias Marti Elisabet Caler Jane M Carlton Ken Simpson Terence P Speed and Alan F Cowman Addresses The Walter and Eliza Hall Institute of Medical Research Melbourne Victoria 3050 Australia. Department of Medical Biology The University of Melbourne Parkville Victoria 3010 Australia. The Institute for Genomic Research TIGR Rockville Maryland 20850 USA. H These authors contributed equally to this work. Correspondence Alan F Cowman. Email cowman@ Published 20 February 2006 Genome Biology 2006 7 RI2 doi I86 gb-2006-7-2-rI2 The electronic version of this article is the complete one and can be found online at http 2006 7 2 RI2 Received 24 October 2005 Revised 20 December 2005 Accepted 23 January 2006 2006 Sargeant et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The apicomplexan parasite Plasmodium falciparum causes the most severe form of malaria in humans. After invasion into erythrocytes asexual parasite stages drastically alter their host cell and export remodeling and virulence proteins. Previously we have reported identification and functional analysis of a short motif necessary for export of proteins out of the parasite and into the red blood cell. Results We have developed software for the prediction of exported proteins in the genus Plasmodium and identified exported proteins conserved between malaria parasites infecting rodents and the two major causes of human malaria P. falciparum and P. vivax. This conserved exportome is confined to a few subtelomeric chromosomal regions in P. falciparum and the synteny of these and surrounding regions