tailieunhanh - Báo cáo sinh học: "All systems GO for understanding mouse gene function"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: All systems GO for understanding mouse gene function. | J. Biol. Journal of Biology BioMed Central Minireview All systems GO for understanding mouse gene function Chris Holmes f and Steve DM Brown Addresses MRC Mammalian Genetics Unit Harwell OX11 0RD UK. Department of Statistics Oxford Centre for Gene Function University of Oxford 1 South Parks Road Oxford OX1 3TG UK. Correspondence Steve DM Brown. E-mail Published 17 December 2004 Journal of Biology 2004 3 20 The electronic version of this article is the complete one and can be found online at http content 3 5 20 2004 BioMed Central Ltd Abstract It is widely supposed that the tissue specificity of gene expression indicates gene function. Now an extensive analysis of gene expression in the mouse reveals that quantitative measurement of expression levels in different tissues can contribute powerfully to the prediction of gene function. With the completion of the human and mouse genome sequences 1-3 the challenge for functional genomics in the twenty-first century is to determine the function of all of the genes that are predicted to be in the mammalian genome. Indeed if we could unscramble the rich relationships between gene variation and disease the impact upon medicine healthcare and lifestyle would be dramatic - as would the effect on our understanding of fundamental biological processes. But the task is daunting and we will need to bring a variety of tools and approaches to bear if we are to undertake a comprehensive and systematic analysis of mammalian gene function. It is humbling to reflect that taking together all of the available information on the sequence expression and mutation of mammalian genes we know little if anything about the physiological function of at least half of the mammalian gene catalog. One approach to discovering gene function in a mammal is to mutate the gene in a mouse and a number of methods are available for introducing mutations into mouse genes. We are likely to see over the next few years a systematic .

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