tailieunhanh - Báo cáo sinh học: "The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. | J. Biol. Journal of Biology BioMed Central Research article Open Access The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal Jens Bose Achim D GrubeC Laura Helming Stefanie Schiebe Ivonne Wegener Martin HafneH Marianne Beales Frank Kontgen and Andreas Lengeling Received 14 May 2004 Revised 16 July 2004 Accepted 21 July 2004 Addresses Junior Research Group Infection Genetics German Research Center for Biotechnology GBF Mascheroder Weg 1 38124 Braunschweig Germany. Department of Pathology School of Veterinary Medicine Hannover Bunteweg 17 30559 Hannover Germany. Department of Experimental Immunology German Research Center for Biotechnology GBF Mascheroder Weg 1 38124 Braunschweig Germany. SQzgene Pty. Ltd. Canning Vale WA 6970 Australia. Correspondence Andreas Lengeling. E-mail lengeling@ Published 23 August 2004 Journal of Biology 2004 3 15 The electronic version of this article is the complete one and can be found online at http content 3Z4 15 2004 Bose et al. licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Phagocytosis of apoptotic cells is fundamental to animal development immune function and cellular homeostasis. The phosphatidylserine receptor Ptdsr on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo we inactivated the Ptdsr gene in the mouse. Results Ablation of Ptdsr function in mice causes perinatal lethality growth retardation and a delay in terminal differentiation of the kidney intestine liver and lungs during embryogenesis. Moreover eye development can be severely .

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