tailieunhanh - Báo cáo sinh học: "Limb regeneration revisited"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Limb regeneration revisited. | Journal of Biology BioMed Central Minireview Limb regeneration revisited Jessica L Whited and Clifford J Tabin Address Department of Genetics Harvard Medical School 77 Avenue Louis Pasteur Boston MA 02115 USA. Correspondence Clifford J Tabin. Email tabin@ Published 13 January 2009 Journal of Biology 2009 8 5 doi jbiol105 The electronic version of this article is the complete one and can be found online at http content 8 1 5 2009 BioMed Central Ltd Abstract The investigation of vertebrate limb regeneration a favorite topic of early developmental biologists is enjoying a renaissance thanks to recently developed molecular and genetic tools as indicated in recent papers in BMC Biology and BMC Developmental Biology. Classical experiments provide a rich context for interpreting modern functional studies. Nearly 240 years have passed since the first scientific treatise addressing limb regeneration Spallanzani s Reproduction of the Legs in the Aquatic Salamander within his An Essay on Animal Reproductions 1 . In spite of extraordinary advances in other areas of developmental biology in the past few decades many of the most remarkable features of limb regeneration outlined by Spallanzani remain mysterious today. However recent advances in genomics and molecular biology offer the potential to finally illuminate the cellular and molecular mechanisms underlying amphibian limb regeneration. Changes in gene expression accompanying regenerative events can now be profiled by microarrays. Recent projects by Monaghan et al. 2 published in BMC Biology and by Pearl et al. 3 in BMC Developmental Biology have provided thousands of cDNA sequences of transcripts expressed during limb regeneration in amphibians. Moreover the newly developed application of transgenesis to axolotl salamanders 4 suggests that functional roles for specific genes are likely to be elucidated in the near future. As these tools are brought to bear on the problem of limb .