tailieunhanh - Báo cáo sinh học: "Budding viral hijackers co-opt the endocytic machinery to make a getaway"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Budding viral hijackers co-opt the endocytic machinery to make a getaway. | J. Biol. Journal of Biology BioMed Central Research news Budding viral hijackers co-opt the endocytic machinery to make a getaway Diane Martindale Published 19 December 2003 Journal of Biology 2003 3 2 The electronic version of this article is the complete one and can be found online at http content 3 1 2 2003 BioMed Central Ltd A retroviral Gag protein interacts with a cellular protein involved in forming endocytic vesicles in a manner that affects the production of virus particles. These findings help define the suite of host-cell components that are usurped by the virus to help it propagate. Viruses are champions when it comes to commandeering the normal biological processes of their hosts. In the case of viruses with small genomes such as the retroviral human immunodeficiency virus HIV and influenza the limited coding capacity of the viral genome forces the virus to use many host cell factors to extend its capabilities during entry into replication within and budding from the cells of its host. There is currently a lot of interest in understanding how retroviruses interact with their hosts. Work in this area not only helps us understand how viruses replicate but also sheds light on normal cellular processes. A great deal of attention has been given to how viruses latch onto cellsurface receptors and hijack other components to enter and replicate in the host cells but much less is known about how they usurp the cellular machinery to orchestrate their exodus. Recently a new model of virus budding has come onto the scene. It posits that enveloped RNA viruses bud by appropriating the endocytic cellular machinery that is normally used to create vesicles inside the cell the formation of vesicles and the budding of a virus are topologically the same process but the reverse of each other. This model has many implications for cell biology and viral pathogenesis and virologists are now busy uncovering how viruses use the machinery of endocytosis to their .

• Báo cáo khoa học
• Báo cáo sinh học hay
• cách trình bày báo cáo
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học