tailieunhanh - Báo cáo y học: "Towards the visualization of genome activity at nanoscale dimensions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Towards the visualization of genome activity at nanoscale dimensions. | Meeting report Towards the visualization of genome activity at nanoscale dimensions Joan C Ritland Politz Address Program in Cell Dynamics Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School 377 Plantation Street Worcester MA 01605 USA. Email Published I February 2006 Genome Biology 2006 7 304 doi gb-2006-7-I-304 The electronic version of this article is the complete one and can be found online at http 2006 7 I 304 2006 BioMed Central Ltd A report on the Fifth Annual Nanostructural Genomics meeting Bar Harbor USA 7-I0 September 2005. It is a rare meeting where one can hear the latest developments in comparative genome analysis relate these findings to advances in understanding both the linear and threedimensional organization of the eukaryotic genome and see it all beginning to fit into the context of the structure and function of the nucleus visualized using state-of-the art labeling and microscopic techniques. These cross-disciplinary areas of research have been presented by a diverse group of scientists for the past five years at the Nanostructural Genomics meeting at the Jackson Laboratory in Bar Harbor and the 2005 meeting again gave attendees much food for thought. In his opening address Timothy O Brien Cornell University Ithaca USA outlined his view of how genomics cell biology and optical physics all work together to create an accurate picture of nuclear structure and function which can lead to important insights into cellular form and function. He discussed his studies of a several megabase region surrounding the mouse piebald locus a genetically defined region named after a coat-color gene within it. He used comparative genomics to learn more about the nature of particular deletions in this region that cause neonatal respiratory distress and death. This information was coupled to high-resolution visualization of gene-rich and gene-poor sections of this region .