tailieunhanh - Báo cáo y học: "What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae? | Research Open Access What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae Diana Ekman Sara Light Ẳsa K Bjorklund and Arne Elofsson Address Stockholm Bioinformatics Center Stockholm University Stockholm Sweden. Correspondence Arne Elofsson. Email arne@ Published 16 June 2006 Genome Biology 2006 7 R45 doi 186 gb-2006-7-6-r45 The electronic version of this article is the complete one and can be found online at http 2006 7 6 R45 Received 06 March 2006 Revised 4 April 2006 Accepted 27 April 2006 2006 Ekman et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Most proteins interact with only a few other proteins while a small number of proteins hubs have many interaction partners. Hub proteins and non-hub proteins differ in several respects however understanding is not complete about what properties characterize the hubs and set them apart from proteins of low connectivity. Therefore we have investigated what differentiates hubs from non-hubs and static hubs party hubs from dynamic hubs date hubs in the protein-protein interaction network of Saccharomyces cerevisiae. Results The many interactions of hub proteins can only partly be explained by bindings to similar proteins or domains. It is evident that domain repeats which are associated with binding are enriched in hubs. Moreover there is an over representation of multi-domain proteins and long proteins among the hubs. In addition there are clear differences between party hubs and date hubs. Fewer of the party hubs contain long disordered regions compared to date hubs indicating that these regions are important for flexible binding but less so for static .