tailieunhanh - Báo cáo y học: "The MAP1 family of microtubule-associated proteins"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The MAP1 family of microtubule-associated proteins. | Protein family review The MAPI family of microtubule-associated proteins Shelley Halpain and Leif Dehmelt Address Department of Cell Biology The Scripps Research Institute and Institute for Childhood and Neglected Diseases 10550 North Torrey Pines Rd La Jolla CA 92037 USA. Correspondence Leif Dehmelt. Email dehmelt@ Published 30 June 2006 Genome Biology 2006 7 224 doi gb-2006-7-6-224 The electronic version of this article is the complete one and can be found online at http 2006 7 6 224 2006 BioMed Central Ltd Summary MAP1-family proteins are classical microtubule-associated proteins MAPs that bind along the microtubule lattice. The founding members MAP1A and MAP1B are predominantly expressed in neurons where they are thought to be important in the formation and development of axons and dendrites. Mammalian genomes usually contain three family members MAP1A MAP1B and a shorter more recently identified gene called MAPIS. By contrast only one family member Futsch is found in Drosophila. After their initial expression the MAP1A and MAP1B polypeptides are cleaved into light and heavy chains which are then assembled into mature complexes together with the separately encoded light chain 3 subunit LC3 . Both MAPlA and MAPlB are well known for their microtubule-stabilizing activity but MAPl proteins can also interact with other cellular components including filamentous actin and signaling proteins. Furthermore the activity of MAPlA and MAPlB is controlled by upstream signaling mechanisms including the MAP kinase and glycogen synthase kinase-3 p pathways. Gene organization and evolutionary history Various classes of microtubule-associated proteins MAPs are expressed in eukaryotic cells. Whereas some MAPs bind specifically to the microtubule plus ends or the minus ends centrosomes many MAPs bind along the microtubule lattice. The latter category includes both enzymatically active MAPs such as microtubule motors or the microtubulesevering .