tailieunhanh - Báo cáo y học: "Viruses take center stage in cellular evolution"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Viruses take center stage in cellular evolution. | Opinion Viruses take center stage in cellular evolution Jean-Michel Claverie Address Structural and Genomic Information Laboratory CNRS-UPR2589 IBSM Parc Scientifique de Luminy 163 Avenue de Luminy case 934 Marseille 13288 cedex 9 France. Email Published 16 June 2006 Genome Biology 2006 7 110 doi gb-2006-7-6-ll0 The electronic version of this article is the complete one and can be found online at http 2006 7 6 ll0 2006 BioMed Central Ltd Abstract The origins of viruses are shrouded in mystery but advances in genomics and the discovery of highly complex giant DNA viruses have stimulated new hypotheses that DNA viruses were involved in the emergence of the eukaryotic cell nucleus and that they are worthy of being considered as living organisms. The reputedly intractable problem of the origin of viruses has long been neglected. In the modern literature virus evolution has come to refer to studies more akin to population genetics such as the worldwide scrutiny of new polymorphisms appearing daily in the H5N1 avian flu virus 1 than to the fundamental question of where viruses come from. This is now rapidly changing as a result of the coincidence of bold new ideas and the revival of old ones the unexpected spectacular features of some recently isolated giant viruses 2 3 as well as the steady increase in the numbers of genomic sequences for regular viruses and cellular organisms which enhances the power of comparative genomics 4 . After being considered non-living and relegated to the wings by most biologists viruses are now center stage they might have been there at the origin of DNA might have played a central role in the emergence of the eukaryotic cell and might even have been the cause of partitioning of biological organisms into the three domains of life Bacteria Archaea and Eukarya. In this article I shall briefly survey some of the recent discoveries and the new evolutionary thoughts they have prompted