tailieunhanh - Báo cáo y học: "The gain and loss of genes during 600 million years of vertebrate evolution"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The gain and loss of genes during 600 million years of vertebrate evolution. | Open Access Research The gain and loss of genes during 600 million years of vertebrate evolution Tine Blomme Klaas Vandepoele Stefanie De Bodt Cedric Simillion Steven Maere and Yves Van de Peer Address Department of Plant Systems Biology Flanders Interuniversity Institute for Biotechnology VIB Ghent University Technologiepark B-9052 Ghent Belgium. Correspondence Yves Van de Peer. Email Published 24 May 2006 Genome Biology 2006 7 R43 doi 186 gb-2006-7-5-r43 The electronic version of this article is the complete one and can be found online at http 2006 7 5 R43 Received 10 February 2006 Revised 27 March 2006 Accepted 3 May 2006 2006 Blomme et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gene duplication is assumed to have played a crucial role in the evolution of vertebrate organisms. Apart from a continuous mode of duplication two or three whole genome duplication events have been proposed during the evolution of vertebrates one or two at the dawn of vertebrate evolution and an additional one in the fish lineage not shared with land vertebrates. Here we have studied gene gain and loss in seven different vertebrate genomes spanning an evolutionary period of about 600 million years. Results We show that first the majority of duplicated genes in extant vertebrate genomes are ancient and were created at times that coincide with proposed whole genome duplication events second there exist significant differences in gene retention for different functional categories of genes between fishes and land vertebrates third there seems to be a considerable bias in gene retention of regulatory genes towards the mode of gene duplication whole genome duplication .