tailieunhanh - Báo cáo y học: "PI3K signaling and miRNA expression during the response of quiescent human fibroblasts to distinct proliferative stimuli"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: PI3K signaling and miRNA expression during the response of quiescent human fibroblasts to distinct proliferative stimuli. | Research Open Access PI3K signaling and miRNA expression during the response of quiescent human fibroblasts to distinct proliferative stimuli Jian Gu and Vishwanath R Iyer Address Section of Molecular Genetics and Microbiology Institute for Cellular and Molecular Biology Center for Systems and Synthetic Biology University of Texas at Austin 1 University Station A4800 Austin TX 78712-0159 USA. Correspondence Vishwanath R Iyer. Email vishy@ Published 31 May 2006 Genome Biology 2006 7 R42 doi 186 gb-2006-7-5-r42 The electronic version of this article is the complete one and can be found online at http 2006 7 5 R42 Received 28 December 2005 Revised 10 March 2006 Accepted 20 April 2006 2006 Gu and Iyer licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Serum treatment of quiescent human dermal fibroblasts induces proliferation coupled with a complex physiological response that is indicative of their normal role in woundhealing. However it is not known to what extent such complex transcriptional events are specific to a given cell type and signal and how these global changes are coordinately regulated. We have profiled the global transcriptional program of human fibroblasts from two different tissue sources to distinct growth stimuli and identified a striking conservation in their gene-expression signatures. Results We found that the wound-healing program of gene expression was not specific to the response of dermal fibroblasts to serum but was regulated more broadly. However there were specific differences among different stimuli with regard to signaling pathways that mediate these transcriptional programs. Our data suggest that the PI3-kinase pathway is differentially .