tailieunhanh - Báo cáo y học: "Influence of metabolic network structure and function on enzyme evolution"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Influence of metabolic network structure and function on enzyme evolution. | Research Open Access Influence of metabolic network structure and function on enzyme evolution Dennis Vitkup Peter Kharchenko and Andreas Wagner Addresses Center for Computational Biology and Bioinformatics Department of Biomedical Informatics Columbia University Russ Berrie Pavilion St Nicholas Avenue New York NY 10032 USA. Department of Genetics New Research Building Ave Louis Pasteur Harvard Medical School Boston MA 02115 USA. Department of Biology Castetter Hall University of New Mexico Albuquerque NM 87131 USA. Correspondence DennisVitkup. Email dv2121@ Published 9 May 2006 Genome Biology 2006 7 R39 doi 186 gb-2006-7-5-r39 The electronic version of this article is the complete one and can be found online at http 2006 7 5 R39 Received 6 September 2005 Revised 9 January 2006 Accepted 7 April 2006 2006 Vitkup et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Most studies of molecular evolution are focused on individual genes and proteins. However understanding the design principles and evolutionary properties of molecular networks requires a system-wide perspective. In the present work we connect molecular evolution on the gene level with system properties of a cellular metabolic network. In contrast to protein interaction networks where several previous studies investigated the molecular evolution of proteins metabolic networks have a relatively well-defined global function. The ability to consider fluxes in a metabolic network allows us to relate the functional role of each enzyme in a network to its rate of evolution. Results Our results based on the yeast metabolic network demonstrate that important evolutionary processes such as the fixation of single .

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