tailieunhanh - Báo cáo y học: "RNA interference pinpoints regulators of cell size and the cell cycle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: RNA interference pinpoints regulators of cell size and the cell cycle. | Minireview RNA interference pinpoints regulators of cell size and the cell cycle Megan J Cully and Sally J Leevers Addresses Signal Transduction Laboratory and fGrowth Regulation Laboratory Cancer Research UK London Research Institute 44 Lincoln s Inn Fields London WC2A 3PX UK. Correspondence Sally J Leevers. Email Published 30 May 2006 Genome Biology 2006 7 219 doi gb-2006-7-5-2l9 The electronic version of this article is the complete one and can be found online at http 2006 7 5 219 2006 BioMed Central Ltd Abstract Cell-based genome-wide RNA interference screens are being used to address an increasingly broad spectrum of biological questions. In one recent screen Drosophila cell cultures treated with double-stranded RNA were analyzed by flow cytometry providing a wealth of new information and identifying 488 regulators of the cell cycle cell size and cell death. The growth of an organism is the net result of a variety of processes including changes in cell size cell division and apoptosis. These processes are regulated by intricate interrelated molecular networks and their disruption can have major biological consequences. In particular the relationship between changes in cell size and the cell cycle has long fascinated researchers. It is complex poorly understood and varies according to the organism tissue type and developmental context. In yeast large-scale genetic screens have uncovered many genes involved in cell growth and the initiation of DNA synthesis S phase 1 2 . It is now clear that yeast cells must grow to a certain minimal size before starting DNA synthesis providing a cell size checkpoint at the transition from the preceding G1 phase to S phase the G1 S transition . Yeast is a unicellular organism however and there is increasing evidence that the relationship between cell growth and cell division may be different in metazoans. Excitingly recent technical advances in high-throughput RNA .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.