tailieunhanh - Báo cáo y học: "The expression signature of in vitro senescence resembles mouse but not human aging"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The expression signature of in vitro senescence resembles mouse but not human aging. | Research Open Access The expression signature of in vitro senescence resembles mouse but not human aging Kristian Wennmalm Claes Wahlestedt and Ola Larsson Addresses Center for Genomics and Bioinformatics Karolinska Institutet Berzelius vag 35 171 77 Stockholm Sweden. ỶUniversity of Minnesota Department of Medicine Minneapolis MN 55455 USA. Correspondence Ola Larsson. E-mail larss004@ Published 16 December 2005 Genome Biology 2005 6 Rl09 doi gb-2005-6-l3-rl09 The electronic version of this article is the complete one and can be found online at http 2005 6 l3 Rl09 Received 16 May 2005 Revised 25 July 2005 Accepted l7 November 2005 2005 Wennmalm et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The biological mechanisms that underlie aging have not yet been fully identified. Senescence a phenomenon occurring in vitro limits the number of cell divisions in mammalian cell cultures and has been suggested to contribute to aging. Results We investigated whether the changes in gene expression that occur during mammalian aging and induction of cellular senescence are similar. We compared changes of gene expression in seven microarray datasets from aging human mouse and rat as well as four microarray datasets from senescent cells of man and mouse. The datasets were publicly available or obtained from other laboratories. Correlation measures were used to establish similarities of the expression profiles and gene ontology analyses to identify functional groups of genes that are co-regulated. Robust similarities were established between aging in different species and tissues indicating that there is an aging transcriptome. Although some cross-species comparisons displayed high