tailieunhanh - Báo cáo y học: "Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe. | Research Open Access Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart Rong Mao Xiaowen Wang Edward L Spitznagel Jr Laurence P Frelin Jason C Ting Huashi Ding Jung-whan Kim Ingo Ruczinski Thomas J Downey and Jonathan Pevsner Addresses Program in Biochemistry Cellular and Molecular Biology Johns Hopkins School of Medicine 1830 East Monument Street Baltimore MD 21205 USA. Department of Neuroscience Johns Hopkins School of Medicine 725 North Wolfe Street Baltimore MD 21205 USA. Partek Incorporated St Charles MO 63304 USA. Department of Mathematics Campus Box 1146 Washington University St Louis MO 63130 USA. Department of Neurology Kennedy Krieger Institute 707 North Broadway Baltimore MD 21205 USA. Pathobiology Graduate Program Johns Hopkins School of Medicine 720 Rutland Avenue Baltimore MD 21205 USA. Department of Biostatistics Johns Hopkins Bloomberg School of Public Health 615 North Wolfe Street Baltimore MD 21205 USA. Correspondence Jonathan Pevsner. E-mail pevsner@ Published 16 December 2005 Genome Biology 2005 6 R107 doi gb-2005-6- 13-r 107 The electronic version of this article is the complete one and can be found online at http 2005 6 13 R107 Received 26 July 2005 Revised 4 October 2005 Accepted 21 November 2005 2005 Mao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Down syndrome caused by trisomic chromosome 21 is the leading genetic cause of mental retardation. Recent studies demonstrated that dosage-dependent increases in chromosome 21 gene expression occur in trisomy 21. However it is unclear whether the entire transcriptome is disrupted or whether there is a more restricted increase in the .