tailieunhanh - Báo cáo sinh học: "Identifying new T -cell regulators?"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Identifying new T -cell regulators. | J. Biol. Journal of Biology BioMed Central Research news Identifying new T-cell regulators Diane Martindale Published 22 September 2003 Journal of Biology 2003 2 17 The electronic version of this article is the complete one and can be found online at http content 2 3 17 2003 BioMed Central Ltd Functional genomic screening for new components of the signaling pathway that is triggered when T cells are activated has identified novel signaling molecules that are potential drug targets. Signaling by the T-cell receptor TCR is a well-trodden cellular pathway and many of the proteins involved have been identified and their function determined in the past two decades. But therapeutic drugs that target these signaling molecules and alter the response of T cells to activation by antigens remain scarce. Uncovering novel proteins on the signaling pathway downstream of activation of the TCR would therefore not only help us to understand immune responses better but also aid in the development of new more effective drugs to treat autoimmune diseases such as lupus and rheumatoid arthritis. But unraveling this complex pathway and identifying all the players is a long and painstaking task. In this issue of Journal of Biology 1 Peter Chu Jorge Pardo Donald Payan Charlene Liao and colleagues describe a large-scale functional genetic screen that is in theory capable of picking up most if not all of the molecules of the TCR signaling pathway. Their work will benefit researchers in immunology and other fields who are eager to identify all the players in a particular signaling pathway see The bottom line box for a summary of the work . Building on the past The bulk of known TCR signaling proteins see the Background box have been uncovered by classical genetic and biochemical methods such as The bottom line A genome-wide functional screening protocol has been developed that has the potential to identify all the signaling molecules involved in the pathway downstream of the T-cell