tailieunhanh - Báo cáo y học: "nferring protein domain interactions from databases of interacting proteins"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: nferring protein domain interactions from databases of interacting proteins. | Method Open Access Inferring protein domain interactions from databases of interacting proteins Robert Riley Christopher Lee Chiara Sabatti and David Eisenberg Addresses Department of Human Genetics David Geffen School of Medicine at UCLA University of California Los Angeles Los Angeles CA 90095 USA. Institute for Genomics and Proteomics University of California Los Angeles Los Angeles CA 90095 USA. Howard Hughes Medical Institute University of California Los Angeles Los Angeles CA 90095-1570 USA. Correspondence David Eisenberg. E-mail david@ Published 19 September 2005 Genome Biology 2005 6 R89 doi 186 gb-2005-6-10-r89 The electronic version of this article is the complete one and can be found online at http 2005 6 10 R89 Received 15 April 2005 Revised 18 July 2005 Accepted 1 7 August 2005 2005 Riley et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We describe domain pair exclusion analysis DPEA a method for inferring domain interactions from databases of interacting proteins. DPEA features a log odds score Ej reflecting confidence that domains i and j interact. We analyzed 177 233 potential domain interactions underlying 26 032 protein interactions. In total 3 005 high-confidence domain interactions were inferred and were evaluated using known domain interactions in the Protein Data Bank. DPEA may prove useful in guiding experiment-based discovery of previously unrecognized domain interactions. Background Post-genomic biological discoveries have confirmed that proteins function in extended networks 1 2 . In particular many proteins must physically bind to other proteins either stably or transiently to perform their functions. The functions of proteins are therefore .