tailieunhanh - Báo cáo y học: "Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. | Research Open Access Changes in gene expression during the development of mammary tumors in MMTV-Wnt-i transgenic mice Shixia Huang n Yi Li Yidong Chen Katrina Podsypanina Mario Chamorro Adam B Olshen Kartiki V Desai Anne Tann David Petersen Jeffrey E Green and Harold E Varmus Addresses Program in Cancer Biology and Genetics Sloan-Kettering Institute New York NY 10021 USA. Breast Center Baylor College of Medicine Houston TX 77030 USA. Department of Medicine Baylor College of Medicine Houston TX 77030 USA. Department of Cell and Molecular Biology Baylor College of Medicine Houston TX 77030 USA. National Human Genome Research Institute National Institutes of Health Bethesda MD 20892 USA. Department of Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer Center New York NY 10021 USA. National Cancer Institute National Institutes of Health Bethesda MD 20892 USA. Johns Hopkins in Singapore Ltd The Nanos Singapore 138669 Republic of Singapore. Correspondence Shixia Huang. E-mail shixiah@ Published 30 September 2005 Genome Biology 2005 6 R84 doi gb-2005-6-l 0-r84 The electronic version of this article is the complete one and can be found online at http 2005 6 10 R84 Received 11 May 2005 Revised 20 July 2005 Accepted 30 August 2005 2005 Huang et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In human breast cancer normal mammary cells typically develop into hyperplasia ductal carcinoma in situ invasive cancer and metastasis. The changes in gene expression associated with this stepwise progression are unclear. Mice transgenic for mouse mammary tumor virus MMTV -Wnt- exhibit discrete steps of mammary tumorigenesis including hyperplasia invasive ductal carcinoma .