tailieunhanh - Báo cáo y học: "oinformatics with a French accent"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Bioinformatics with a French accent. | Meeting report Bioinformatics with a French accent Laurence D Hurst and Laurent Duret Addresses Department of Biology and Biochemistry University of Bath Bath BA2 7AY UK. fPole BioInformatique Lyonnais Laboratoire BBE - UMR CNRS 5558 Université Claude Bernard - Lyon 1 F-69622 Villeurbanne Cedex France. Correspondence Laurence D Hurst. E-mail . Laurent Duret. E-mail duret@ Published 28 September 2005 Genome Biology 2005 6 349 doi gb-2005-6-10-349 The electronic version of this article is the complete one and can be found online at http 2005 6 10 349 2005 BioMed Central Ltd A report on the bioinformatics conference JOBIM Journees ouvertes biologie informatiques mathématiques Lyon France 6-8 July 2005. Those with a fondness for Brazilian music will know of Antônio Carlos Jobim best known to the rest of us as the composer of The Girl From Ipanema . JOBIM is also the annual gathering of the French bioinformatics community. The title is no accident the acronym being proposed by a French-Brazilian bioinformatician with a taste we presume for the bossa nova. This year JOBIM was held in Lyon and provided the opportunity to catch a cross-section of the challenges and opportunities opening up in the data-rich world of genomics and post-genomics. Handling chips For expression-related datasets the emphasis was very much on the challenges they pose. Although microarray data seem in principle a remarkable means to capture vast amounts of expression information the quality of the data was of concern to many. Julie Aubert L Institut National Agronomique Paris-Grignon INAPG Paris France described the systematic and gene-specific dye-bias effects that have been observed in dual-color microarray experiments. The systematic effects may be normalized away but the gene-specific effects are more troublesome. She proposed a method label bias index LBI for measuring such an effect and reported that after normalization this