tailieunhanh - Báo cáo y học: "Identification of cyanobacterial non-coding RNAs by comparative genome analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of cyanobacterial non-coding RNAs by comparative genome analysis. | Research Open Access Identification of cyanobacterial non-coding RNAs by comparative genome analysis Ilka M AxmannH Philip KenscheH Jorg Vogel Stefan Kohl Hanspeter Herzel and Wolfgang R Hess Addresses Humboldt-University Department of Biology Genetics Chausseestrasse D-Berlin Germany. Humboldt-University Institute for Theoretical Biology Invalidenstrasse Berlin Germany. Max Planck Institute for Infection Biology Schumannstrasse Berlin Germany. University Freiburg Institute of Biology II Experimental Bioinformatics Schanzlestrasse Freiburg Germany. H These authors contributed equally to this work. Correspondence Wolfgang R Hess. E-mail Published 17 August 2005 Genome Biology 2005 6 R73 doi 186 gb-2005-6-9-r73 The electronic version of this article is the complete one and can be found online at http 2005 6 9 R73 Received 30 March 2005 Revised 1 June 2005 Accepted 20 July 2005 2005 Axmann et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Whole genome sequencing of marine cyanobacteria has revealed an unprecedented degree of genomic variation and streamlining. With a size of megabase-pairs Prochlorococcus sp. MED4 has the most compact of these genomes and it is enigmatic how the few identified regulatory proteins efficiently sustain the lifestyle of an ecologically successful marine microorganism. Small non-coding RNAs ncRNAs control a plethora of processes in eukaryotes as well as in bacteria however systematic searches for ncRNAs are still lacking for most eubacterial phyla outside the enterobacteria. Results Based on a computational prediction we show the presence of several ncRNAs cyanobacterial functional RNA or Yfr in several .