tailieunhanh - Báo cáo y học: "The first decade of microbial genomics: what have we learned and where are we going next"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The first decade of microbial genomics: what have we learned and where are we going next? | Meeting report The first decade of microbial genomics what have we learned and where are we going next David A Rasko and Emmanuel F Mongodin Address The Institute for Genomic Research 9712 Medical Center Drive Rockville MD 20850 USA. Current address Department of Microbiology University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard Dallas TX 75390-9048 USA. Correspondence David A Rasko. E-mail Published 30 August 2005 Genome Biology 2005 6 341 doi gb-2005-6-9-34l The electronic version of this article is the complete one and can be found online at http 2005 6 9 341 2005 BioMed Central Ltd A report on the International Conference on Microbial Genomics Halifax Canada 13-16 April 2005. It is now a decade since the first microbial genome was sequenced. Although genomics is still in its infancy and the best is hopefully still to come amazing strides have been made since the completion in 1995 of the first genome sequence of a free-living organism the bacterium Haemophilus influenzae. Just ten years later 261 microbial genomes have been completed and an additional 669 are in progress. We have progressed from sequencing a single bacterial isolate assuming that it was an adequate reference for that species to metagenomics - sequencing an entire microbial community. We are just starting to discover the complexity and dynamic nature of the microbial world which raises further questions. For example what is a bacterial species How many isolates need to be sequenced to capture the diversity of a single species During the course of the recent International Conference on Microbial Genomics held in Canada the question of what is a bacterial species was raised and discussed on many occasions. As pointed out by W. Ford Doolittle Dalhousie University Halifax Canada the notion of a bacterial species is classically defined as a uniform and stable way for naming groups of similar bacteria . On the .