tailieunhanh - Báo cáo y học: "Datasets for evolutionary comparative genomics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Datasets for evolutionary comparative genomics. | Opinion Datasets for evolutionary comparative genomics David A Liberies Address Computational Biology Unit Bergen Centre for Computational Science University of Bergen 5020 Bergen Norway. E-mail liberles@ Published 28 July 2005 Genome Biology 2005 6 117 doi gb-2005-6-8-117 The electronic version of this article is the complete one and can be found online at http 2005 6 8 117 2005 BioMed Central Ltd Abstract Many decisions about genome sequencing projects are directed by perceived gaps in the tree of life or towards model organisms. With the goal of a better understanding of biology through the lens of evolution however there are additional genomes that are worth sequencing. One such rationale for whole-genome sequencing is discussed here along with other important strategies for understanding the phenotypic divergence of species. Bioinformaticists and computational biologists working in the field of comparative genomics are largely dependent on datasets generated by others. Working with available data opens up desires for complementary datasets to fill knowledge gaps. In addition to writing grants for experimental laboratories and molecular biology supplies one can also write an opinion piece to convince others to do some of the dirty work for you this is what I am attempting to do here. Comparative genomics starts with sequencing. Many have suggested gaps in the tree of life where additional genome projects will augment current knowledge either to shorten long branches on the tree of sequenced genomes or to complement existing genome projects. For example there remain huge gaps in our knowledge of archaea. But with the faith that these gaps will ultimately be filled in in this article I focus on alternative strategies for directing genomic resources so as to answer fundamental questions in evolution. The tape of life A whole class of genomic experiments can be hypothesized through what can be called the tape of life question. .