tailieunhanh - Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins. | Research Open Access Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins Shiri Freilich Tim Massingham Sumit Bhattacharyya Hannes Ponstingl Paul A Lyons Tom C Freeman and Janet M Thornton Addresses EMBL-EBI Wellcome Trust Genome Campus Cambridge CB10 1SB UK. Rosalind Franklin Centre Genomics Research Wellcome Trust Genome Campus Cambridge CB10 1SB UK. Correspondence Shiri Freilich. E-mail shirigo@ Published 29 June 2005 Genome Biology 2005 6 R56 doi 186 gb-2005-6-7-r56 The electronic version of this article is the complete one and can be found online at http 2005 6 7 R56 Received 17 February 2005 Revised 11 April 2005 Accepted 1 1 May 2005 2005 Freilich et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by Abstract Background The combination of complete genome sequence information with expression data enables us to characterize the relationship between a protein s evolutionary origin or functional category and its expression pattern. In this study mouse proteins were assigned into functional and phyletic groups and the gene expression patterns of the different protein groupings were examined by microarray analysis in various mouse tissues. Results Our results suggest that the proteins that are universally distributed in all tissues are predominantly enzymes and transporters. In contrast the tissue-specific set is dominated by regulatory proteins signal transduction and transcription factors . An increased tendency to tissuespecificity is observed for metazoan-specific proteins. As the composition of the phyletic groups highly correlates with that of the functional groups the data were tested in order to determine which of the two factors - function or phyletic age - is dominant in shaping the expression profile of a protein. The observed