tailieunhanh - Báo cáo y học: "Quantitative genomics of starvation stress resistance in Drosophila"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Quantitative genomics of starvation stress resistance in Drosophila. | Research Open Access Quantitative genomics of starvation stress resistance in Drosophila Susan T Harbison Sherman Chang Kim P Kamdar and Trudy FC Mackay Addresses Department of Genetics North Carolina State University Raleigh NC 27695 USA. WM Keck Center for Behavioral Biology North Carolina State University Raleigh NC 27695 USA. The Torrey Mesa Research Institute 3115 Merryfield Row San Diego CA 92121 USA. Current address Department of Neuroscience University of Pennsylvania Medical School Philadelphia PA 19104 USA. Correspondence Trudy FC Mackay. E-mail trudy_mackay@ Published 24 March 2005 Genome Biology 2005 6 R36 doi 186 gb-2005-6-4-r36 The electronic version of this article is the complete one and can be found online at http 2005 6 4 R36 Received 24 August 2004 Revised 22 December 2004 Accepted 23 February 2005 2005 Harbison et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A major challenge of modern biology is to understand the networks of interacting genes regulating complex traits and the subset of these genes that affect naturally occurring quantitative genetic variation. Previously we used P-element mutagenesis and quantitative trait locus QTL mapping in Drosophila to identify candidate genes affecting resistance to starvation stress and variation in resistance to starvation stress between the Oregon-R Ore and 2b strains. Here we tested the efficacy of whole-genome transcriptional profiling for identifying genes affecting starvation stress resistance. Results We evaluated whole-genome transcript abundance for males and females of Ore 2b and four recombinant inbred lines derived from them under control and starved conditions. There were significant .