tailieunhanh - Báo cáo y học: "The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. | Research Open Access The interferon-inducible p47 IRG GTPases in vertebrates loss of the cell autonomous resistance mechanism in the human lineage Cemalettin Bekpen Julia P Hunn Christoph Rohde lana Parvanova Libby Guethlein Diane M Dunn Eva Glowalla Maria Leptin and Jonathan C Howard Addresses Institute for Genetics University of Cologne Zulpicher Strasse 47 50674 Cologne Germany. Eccles Institute of Human Genetics University of Utah Salt Lake City UT 84112-5330 USA. Informatics Systems Groups Sanger Centre The Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. Department of Structural Biology Stanford University Medical School Stanford CA 94305 USA. Institute for Microbiology and Immunology University of Cologne Medical School 50935 Cologne Germany. Correspondence Jonathan C Howard. E-mail Published 31 October 2005 Genome Biology 2005 6 R92 doi 186 gb-2005-6-1 1-r92 The electronic version of this article is the complete one and can be found online at http 2005 6 11 R92 Received 4 June 2005 Revised 7 September 2005 Accepted 7 October 2005 2005 Bekpen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Members of the p47 immunity-related GTPases IRG family GTPases are essential interferon-inducible resistance factors in mice that are active against a broad spectrum of important intracellular pathogens. Surprisingly there are no reports of p47 function in humans. Results Here we show that the p47 GTPases are represented by 23 genes in the mouse whereas humans have only a single full-length p47 GTPase and an expressed truncated presumed pseudogene. The human full-length gene is orthologous to an isolated mouse p47 GTPase that carries no .