tailieunhanh - Báo cáo y học: "Genomic studies of mood disorders - the brain as a muscle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genomic studies of mood disorders - the brain as a muscle? | Minireview Genomic studies of mood disorders - the brain as a muscle Alexander B Niculescu Address Institute of Psychiatric Research Indiana University School of Medicine 791 Union Drive Indianapolis IN 46202-4887 USA. E-mail anicules@ Published 24 March 2005 Genome Biology 2005 6 215 doi gb-2005-6-4-2l5 The electronic version of this article is the complete one and can be found online at http 2005 6 4 215 2005 BioMed Central Ltd Abstract Recent genomic studies showing abnormalities in the fibroblast growth factor system in the postmortem brains of people with major depressive disorder support previous indications of a role for growth factors in mood disorders. Similar molecular pathways volumetric changes and the effects of exercise on mood suggest a superficial analogy and perhaps a deeper relationship between muscle and brain functioning. An evolutionary perspective on mood disorders Mood - the way one feels inside emotionally - is likely to have evolved broadly speaking as a sensor and integrator of the environmental availability or lack of availability of resources that an organism needs to live to develop and to propagate its genes. A non-nurturing hostile environment engenders low mood and depression. This is useful in making the organism conserve existing resources keep still and stay out of harm s way 1 2 . Conversely a nurturing favorable environment engenders high mood and euphoria making the organism more likely to take advantage of opportunities to expand and to propagate its genes. The switch from low to high mood becomes loose in bipolar manic-depressive illness and overreacts to minor stimuli in an excessive and persistent fashion that often obscures any correlation with external events that trigger the switch. The incongruence between mood and environment is a hallmark of severe clinical depression or mania. In severe clinical depression also called major depressive disorder mood is low even in favorable .