tailieunhanh - Báo cáo y học: "A DNA microarray survey of gene expression in"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A DNA microarray survey of gene expression in. | Research Open Access A DNA microarray survey of gene expression in normal human tissues Radha Shyamsundar Young H Kim John P Higgins Kelli Montgomery Michelle Jorden Anand Sethuraman Matt van de Rijn David Botstein Patrick O Brown and Jonathan R Pollack Addresses Department of Pathology Stanford University School of Medicine 269 Campus Drive CCSR 3245A Stanford CA 94305-5176 USA. ỶDepartment of Biochemistry Stanford University School of Medicine 279 Campus Drive Stanford CA 94305-5307 USA. Department of Genetics Stanford University Stanford CA 94305 USA. Howard Hughes Medical Institute Stanford University School of Medicine 279 Campus Drive Stanford CA 94305-5307 USA. Lewis-Sigler Institute for Integrative Genomics Princeton University Princeton NJ 80544 USA. Correspondence PatrickO Brown. E-mail pbrown@. Jonathan R Pollack. E-mail pollacki@ Published 14 February 2005 Genome Biology 2005 6 R22 The electronic version of this article is the complete one and can be found online at http 2005 6 3 R22 Received 29 November 2004 Revised 14 January 2005 Accepted 18 January 2005 2005 Shyamsundar et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Numerous studies have used DNA microarrays to survey gene expression in cancer and other disease states. Comparatively little is known about the genes expressed across the gamut of normal human tissues. Systematic studies of global gene-expression patterns by linking variation in the expression of specific genes to phenotypic variation in the cells or tissues in which they are expressed provide clues to the molecular organization of diverse cells and to the potential roles of the genes. Results Here we describe a .