tailieunhanh - Báo cáo y học: "Genome informatics: taming the avalanche of genomic data"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Genome informatics: taming the avalanche of genomic data. | Meeting report Genome informatics taming the avalanche of genomic data Erik LL Sonnhammer Address Center for Genomics and Bioinformatics Karolinska Institutet 171 77 Stockholm Sweden. E-mail Published 17 December2004 Genome Biology 2004 6 301 The electronic version of this article is the complete one and can be found online at http 2004 6 l 30l 2004 BioMed Central Ltd A report on the fourth Cold Spring Harbor Laboratory Wellcome Trust Conference on Genome Informatics Hinxton UK 22-26 September 2004. The pace of genomic data generation has recently accelerated substantially particularly for higher eukaryotes. The genome sequences of more than a dozen multicellular eukaryotes are now finished and complementary information such as expressed sequence tags ESTs and data on gene expression protein-protein interactions single-nucleotide polymorphisms SNPs and proteomics are being generated in high-throughput mode. To make sense of this flood of heterogeneous data and make it useful to scientists powerful informatics systems are being put in place. The Cold Spring Harbor Laboratory Wellcome Trust conference on genome informatics focused both on informatics technologies for data storage and processing as well as on the latest discoveries gained by analyzing genomic data. The many blessings of multiple genome sequences Once the human genome sequence was underway scientists realized that the only way to decode it fully was to sequence a number of related genomes as well. The mouse and chimpanzee genomes have now been completed as well as those of some other animals and this has helped genome annotation tremendously. In particular functional but nonprotein-coding parts of the human genome could be identified by looking for sequence conservation between different genomes. For example the presence of ultraconserved regions was completely unexpected thousands of regions of more than 100 base-pairs bp are 100 conserved between different