tailieunhanh - Báo cáo y học: "Why genomics is more than genomes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Why genomics is more than genomes. | Meeting report Why genomics is more than genomes Jeffrey G Lawrence Address Department of Biological Sciences University of Pittsburgh Pittsburgh PA 15260 USA. E-mail jlawrenc@ Published 16 November 2004 Genome Biology 2004 5 357 The electronic version of this article is the complete one and can be found online at http 2004 5 l2 357 2004 BioMed Central Ltd A report on the 2004 meeting on Molecular Genetics of Bacteria and Bacteriophages Cold Spring Harbor USA 2529 August 2004. The meetings on the molecular genetics of bacteria and bacteriophages are the oldest and smallest of the conferences that originated at the Cold Spring Harbor Laboratory which was the venue for this year s meeting. The toolbox of molecular genetics has expanded immensely since the first of the phage meetings was held at Cold Spring Harbor in the 1950s. Then bacteriophages were used as model systems to elucidate fundamental aspects of biology at the molecular level including the nature of mRNA colinearity of genes and proteins the action of restriction enzymes and DNA ligase roles of molecular chaperones and anti-termination. Much was understood in the absence of genomic data. Ultimately the release of the complete genome sequence of bacteriophage X in 1982 perhaps raised more questions about X biology than it answered. Complete genome sequences of prokaryotes number nearly 200 at the time of writing and they offer a powerful route to understanding aspects of a microorganism s biology. Yet as shown at the 2004 meeting there are always new aspects of biology to be discovered that are not at all evident from a genome sequence but are crucial for its interpretation. Successful inference of gene regulation from genome sequences has progressed steadily in the past few decades as the binding sites for regulatory proteins have become better characterized and algorithms for finding cognate sites have improved. Yet the ability to make inferences about regulation on the basis .