tailieunhanh - Báo cáo y học: "How biologically relevant are interaction-based modules in protein networks"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: How biologically relevant are interaction-based modules in protein networks? | Method Open Access How biologically relevant are interaction-based modules in protein networks Juan F Poyatos and Laurence D HursL Addresses Evolutionary Systems Biology Initiative Structural and Computational Biology Program Spanish National Cancer Center CNIO Melchor Fernández Almagro 3 28029 Madrid Spain. ỶDepartment of Biology and Biochemistry University of Bath Bath BA2 7AY UK. Correspondence Juan F Poyatos. E-mail jpoyatos@ Published I November 2004 Genome Biology 2004 5 R93 The electronic version of this article is the complete one and can be found online at http 2004 5 11 R93 Received 17 July 2004 Revised 3 1 August 2004 Accepted 1 October 2004 2004 Poyatos and Hurst licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract By applying a graph-based algorithm to yeast protein-interaction networks we have extracted modular structures and show that they can be validated using information from the phylogenetic conservation of the network components. We show that the module cores the parts with the highest intramodular connectivity are biologically relevant components of the networks. These constituents correlate only weakly with other levels of organization. We also discuss how such structures could be used for finding targets for antimicrobial drugs. Background There is a strong belief underpinning systems biology that between the individual molecules and an organism s phenotype there exist intermediary levels of organization 1 . The lowest level and one that can be objectively defined is that of the motif for example a feedforward loop 2-5 . At the next level there exist putative modules within networks 6-16 . However unlike motifs modules are not objectively defined and are hence rather .