tailieunhanh - Báo cáo y học: "Uncovering the complexities of Kaposi’s sarcoma through genomewide expression analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Uncovering the complexities of Kaposi’s sarcoma through genomewide expression analysis. | Minireview Uncovering the complexities of Kaposi s sarcoma through genome wide expression analysis Daniel Di Bartolo and Ethel Cesarman Address Weill Medical College of Cornell University New York NY 10021 USA. Correspondence Ethel Cesarman. E-mail ecesarm@ Published I November 2004 Genome Biology 2004 5 247 The electronic version of this article is the complete one and can be found online at http 2004 5 11 247 2004 BioMed Central Ltd Abstract Gene-expression profiling of endothelial cells infected with Kaposi s sarcoma-associated herpesvirus has led to a greater understanding of the histogenesis of Kaposi s sarcoma and the cellular reprogramming events that occur as a result of viral infection and that may play important roles in viral pathogenesis. Kaposi s sarcoma KS is a peculiar neoplasm that has a diverse cellular makeup and an extensive neovasculature. Because of the complexity of this vascular proliferative disorder there are several questions that remain unanswered. Recently several groups have used gene-expression microarrays in an effort to better understand the nature and pathogenesis of KS 1-5 . KS was first identified in 1872 by Moritz Kaposi a Hungarian dermatologist who described it as an idiopathic multiple pigmented sarcoma of the skin which was lethal in his patients 6 . This classical form of KS was further described as a rare indolent disease predominantly found in older men of Mediterranean and Eastern European descent. In the 1950s endemic KS a more aggressive form of KS was identified in parts of sub-Saharan Africa. Shortly thereafter an iatrogenic form of KS was diagnosed in immunosuppressed organ-transplant patients. A fourth form of KS epidemic KS was identified in the 1980s initially in homosexual men with acquired immune deficiency syndrome AIDS . The epidemiology of KS - in particular its geographical distribution as well as its prevalence in gay men - suggested that there was an infectious etiological