tailieunhanh - Structural genomics and structural biology: compare and contrast

Published: 25 August 2004 Genome Biology 2004, 5:343 The electronic version of this article is the complete one and can be found online at © 2004 BioMed Central Ltd reports A report on the Keystone Symposium ‘Structural Genomics’, held concurrently with the ‘Frontiers in Structural Biology’ symposium, Snowbird, USA, 13-19 April 2004. | Meeting report Structural genomics and structural biology compare and contrast John-Marc Chandonia Thomas N Earnest and Steven E Brenner Addresses Berkeley Structural Genomics Center and Physical Biosciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA. Department of Plant and Microbial Biology 461A Koshland Hall University of California Berkeley CA 94720-3102 USA. Correspondence Steven E Brenner. E-mail brenner@ Published 25 August 2004 Genome Biology 2004 5 343 The electronic version of this article is the complete one and can be found online at http 2004 5 9 343 2004 BioMed Central Ltd A report on the Keystone Symposium Structural Genomics held concurrently with the Frontiers in Structural Biology symposium Snowbird USA 13-19 April 2004. Is structural genomics a visionary undertaking heralding the future of structural biology or merely a billion-dollar-plus folly Two concurrent Keystone Symposia Structural Genomics and Frontiers in Structural Biology brought together leading structural biologists and pioneers of the structural genomics community providing an exciting opportunity to contrast cutting-edge advances in the two fields. The advances in structural genomics have focused on providing value for money improved automation has resulted in expanded productivity. We expect the resulting flood of structures to provide an essential platform for future biological and medical research - just as genome-sequencing projects enabled new avenues of research for example on the noncoding regions of DNA. In contrast recent structural biology work has provided a tremendous amount of detail on specific biological mechanisms including many areas that were previously beyond our technological capabilities to study. Results from structural genomics consortia In the US the National Institutes of Health NIH are currently sponsoring nine pilot structural genomics centers through the Protein Structure Initiative PSI . .

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