tailieunhanh - DRUG DISCOVERY AND DEVELOPMENT – PRESENT AND FUTURE

Serum prostate specific antigen (PSA) is the only biomarker routinely used for the early detection of prostate cancer, but it is not a perfect test. Although PSA is highly specific for prostate, an elevated level is not specific for cancer, being increased in benign hyperplasia and prostatitis (Pungalia, 2006; Bozeman, 2002). Consequently, the majority of men with an increased serum PSA do not have prostate cancer and thus undergo unnecessary prostate biopsies. Data from the USA estimate that of the million prostate biopsies performed annually, only 235,000 cases of cancer are detected, or that more than 750,000 men underwent a biopsy based on an elevated PSA caused by. | DRUG DISCOVERY AND DEVELOPMENT -PRESENT AND FUTURE Edited by Izet M. Kapetanovic Drug Discovery and Development - Present and Future Edited by Izet M. Kapetanovic Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Ivana Zec Technical Editor Teodora Smiljanic Cover Designer InTech Design Team Image Copyright Olga Miltsova 2011. Used under license from First published December 2011 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Drug Discovery and Development - Present and Future Edited by Izet