tailieunhanh - Báo cáo sinh học: " Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree?"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree? | Cierco-Ayrolles et al. Genetics Selection Evolution 2010 42 38 http content 42 1 38 Ge n et i cs Selection Evolution RESEARCH Open Access Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree H ri ci no Ciarrn- A m I Io c Qoh cfion rìoíoTỉn2 Annlróc I 3 I lolono f ilHort 4 Trim p lri lot 3 Plnronno Vfm imol6 Ciiiisuie Cieico Ayiolles Sébdsuei Dejedi Aidiés Legdiid ncicnc GilbeiL ium Diuei rloieice Iiouiiel Delphine Estivdls1 Ndimd Oumouhou1 Brigitte Mdigii1 Abstract Background Slice 2001 the use of moie did moie deise mdps hds mdde resedrchers dwdie thdt combiiiig liikdge did liikdge disequillbilum eihdices the fedsibility of fiie-mdppiig geies of iiteiest. So vdiious method types hdve beei derived to iiclude coicepts of populdtioi geietics ii the didlyses. Oie mdjoi didwbdck of mdiy of these methods is theii computdtioidl cost which is veiy sigiificdit whei mdiy mdikeis die coisideied. Receit ddvdices ii technology such ds SNP geiotypiig hdve mdde it possible to dedl with huge dmouit of ddtd. Thus the chdlleige thdt iemdiis is to fiid dccuidte did efficieit methods thdt die iot too time coisumiig. The study iepoited heie specificdlly focuses oi the hdlf-sib fdmily diimdl desigi. Oui objective wds to deteimiie whethei modelliig of liikdge disequilibrium evolutioi improved the mdppiig dccuidcy of d qudititdtive tidit locus of dgiicultuidl iiteiest ii these populdtiois. We compdied two methods of fiie-mdppiig. The fiist oie wds di dssocidtioi didlysis. Ii this method we did iot model liikdge disequilibiium evolutioi. Theiefoie the modelliig of the evolutioi of liikdge disequilibiium wds d deteimiiistic process it wds complete dt time 0 did iemdiied complete duiiig the followiig geieidtiois. li the secoid method the modelliig of the evolutioi of populdtioi dllele fiequeicies wds derived fiom d Wiight-Fishei model. We simuldted d wide idige of sceidiios dddpted to diimdl populdtiois .