tailieunhanh - Báo cáo sinh học: "Selection against genetic defects in conservation schemes while controlling inbreeding"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Selection against genetic defects in conservation schemes while controlling inbreeding | 353 Genet. Sel. Evol. 35 2003 353-368 INRA EDP Sciences 2003 DOI gse 2003028 Original article Selection against genetic defects in conservation schemes while controlling inbreeding Anna K. Sonesson Luc . Janss Theo . Meuwissen Institute of Animal Science and Health ID-Lelystad PO Box 65 8200 AB Lelystad The Netherlands Received 9 April 2002 accepted 15 January 2003 Abstract - We studied different genetic models and evaluation systems to select against a genetic disease with additive recessive or polygenic inheritance in genetic conservation schemes. When using optimum contribution selection with a restriction on the rate of inbreeding AF to select against a disease allele selection directly on DNA-genotypes is as expected the most efficient strategy. Selection for BLUP or segregation analysis breeding value estimates both need 1-2 generations more to halve the frequency of the disease allele while these methods do not require knowledge of the disease mutation at the DNA level. BLUP and segregation analysis methods were equally efficient when selecting against a disease with single gene or complex polygene inheritance . knowledge about the mode of inheritance of the disease was not needed for efficient selection against the disease. Smaller schemes or schemes with a more stringent restriction on AF needed more generations to halve the frequency of the disease alleles or the fraction of diseased animals. Optimum contribution selection maintained AF at its predefined level even when selection of females was at random. It is argued that in the investigated small conservation schemes with selection against a genetic defect control of AF is very important. genetic defects selection inbreeding conservation 1. INTRODUCTION Many domesticated animal populations show heritable defects. Some defects are inherited by a single gene . complex vertebral malformation CVM in cattle 1 . Other diseases have a complex inheritance involving Correspondence and .

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