tailieunhanh - Báo cáo sinh học: " Introgression of a major QTL from an inferior into a superior population using genomic selection"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Introgression of a major QTL from an inferior into a superior population using genomic selection | Genetics Selection Evolution BioMed Central Research Introgression of a major QTL from an inferior into a superior population using genomic selection Jorgen 0degârd 1 2 Anna K Sonesson1 M Hossein Yazdi2 and Theo HE Meuwissen2 Address 1Nofima Marine PO Box 5010 NO-1432 As Norway and 2Department of Animal and Aquacultural Sciences Norwegian University of Life Sciences PO Box 5003 NO-1432 As Norway Email Jorgen 0degârd - Anna K Sonesson - M Hossein Yazdi - Theo HE Meuwissen - Corresponding author Open Access Published 27 July 2009 Received 12 January 2009 Genetics Selection Evolution 2009 41 38 doi 1297-9686-41 -38 Accepted 27 July 2009 This article is available from http content 41 1 38 2009 0degảrd et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Selection schemes aiming at introgressing genetic material from a donor into a recipient line may be performed by backcross-breeding programs combined with selection to preserve the favourable characteristics of the donor population. This stochastic simulation study investigated whether genomic selection can be effective in preserving a major quantitative trait locus QTL allele from a donor line during the backcrossing phase. Methods In a simulation study two fish populations were generated a recipient line selected for a production trait and a donor line characterized by an enhanced level of disease resistance. Both traits were polygenic but one major QTL affecting disease resistance was segregating only within the donor line. Backcrossing was combined with three types of selection for total merit index among the crossbred individuals .