tailieunhanh - Báo cáo hóa học: " Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules | Nanoscale Res Lett 2010 5 1561-1569 DOI s11671-010-9677-z NANO EXPRESS Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules Huafeng Zhou Yang Yue Guanlan Liu Yan Li Jing Zhang Zemin Yan Mingxing Duan Received 10 March 2010 Accepted 29 June 2010 Published online 20 July 2010 The Author s 2010. This article is published with open access at Abstract The purpose of this study was to investigate the influence of the inner lipid ratio on the physicochemical properties and skin targeting of surfactant-free lecithinbased coenzyme Q10-loaded lipid nanocapsules CoQ10-LNCs . The smaller particle size of CoQ10-LNCs was achieved by high pressure and a lower ratio of CoQ10 GTCC Caprylic capric triglyceride however the zeta potential of CoQ10-LNCs was above 60 mV with no distinct difference among them at different ratios of CoQ10 GTCC. Both the crystallisation point and the index decreased with the decreasing ratio of CoQ10 GTCC and smaller particle size interestingly the supercooled state of CoQ10-LNCs was observed at particle size below about 200 nm as verified by differential scanning calorimetry DSC in one heating-cooling cycle. The lecithin monolayer sphere structure of CoQ10-LNCs was investigated by cryogenic transmission electron microscopy Cryo-TEM . The skin penetration results revealed that the distribution of Nile red-loaded CoQ10-LNCs depended on the ratio of inner CoQ10 GTCC moreover epidermal targeting and superficial dermal targeting were achieved by the CoQ10-LNCs application. The highest fluorescence response was observed at a ratio of inner CoQ10 GTCC of 1 1. These observations suggest that lecithin-based LNCs could be used as a promising topical delivery vehicle for lipophilic compounds. H. Zhou Y. Yue G. Liu Y. Li J. Zhang M. Duan State-key Laboratory of Biomembrane and Membrane Biotechnology School of Life Sciences Tsinghua University 100084 Beijing China e-mail duanmx@ H.