tailieunhanh - obstetrics_part11

Nifedipine (Adalat ®, Adalat ® LA .) Prescription dưới tác động y tế điều trị giám sát - Tử cung giãn - thuốc hạ áp (chẹn kênh canxi) - bị đe dọa sinh non - Tăng huyết áp - 10 mg tác dụng ngắn () viên nang chứa đầy chất lỏng - 10 mg viên thuốc phóng thích kéo dài Cũng có 20 mg | NIFEDIPINE Adalat Adalat LA. Prescription under medical supervision Therapeutic action - Uterine relaxant - Antihypertensive drug calcium channel blocker Indications - Threatened premature labour - Hypertension Presentation - 10 mg short-acting liquid-filled capsule - 10 mg prolonged-release tablet Also comes in 20 mg 30 mg 60 mg and 90 mg prolonged-release tablets to be administered once daily or to be administered twice daily. Follow manufacturer s instructions. Dosage - Threatened premature labour short-acting capsule 10 mg by oral route to be repeated every 15 minutes if uterine contractions persist maximum 4 doses or 40 mg then 20 mg by oral route every 6 hours - Hypertension prolonged-release tablets 20 to 100 mg day in 2 divided doses or 20 to 90 mg once daily depending on the preparation used Duration - Threatened premature labour 48 hours - Hypertension lifetime treatment Contra-indications adverse effects precautions - Do not administer to patients with severe cardiac disease recent myocardial infarction unstable angina . - Do not administer if systolic blood pressure is below 90 mmHg. - May cause headache flushing peripheral oedema common adverse effects at the start of treatment dizziness hypotension tachycardia nausea gingival hyperplasia rash. - Stop nifedipine if ischaemic chest pain occurs or existing pain increases shortly after starting treatment. - Do not combine with magnesium sulphate salbutamol IV and calcium channel blockers. - Monitor combination with cimetidine additive hypotension phenytoin risk of phenytoin toxicity rifampicin efficacy of nifedipine diminished itraconazole increased risk of oedema beta-blockers enhanced antihypertensive effects . - Pregnancy CONTRA-INDICATED during the 1st trimester. Never administer sublingually risk of foetal death from placental hypoperfusion . - Breast-feeding avoid Remarks - Methyldopa and beta-blockers are the drugs of choice for treating hypertension in pregnancy. - Short-acting formulations of .