tailieunhanh - MORPHOGENESIS THE CELLULAR AND MOLECULAR PROCESSES OF DEVELOPMENTAL ANATOMY

In 1895, Roux set out the problems confronting the new subject of experimental embryology and commented that, although he and his peers intended to simplify what was clearly a very complicated set of events, they knew so little about development that they would be unable to elucidate the underlying mechanisms without a great deal of work. Moreover, because they were so ignorant, they could not know which approaches would be the most helpful in their attempts to gain understanding. The initial result of any research in the area would therefore be to make the situation appear even more complicated than it already was and it would take some. | Morphogenesis the generation of tissue organisation in embryos is becoming an increasingly important subject. This is partly because the techniques for investigating many morphogenetic mechanisms have only recently become available and partly because studying the genomic basis of embryogenesis requires an understanding of the developmental phenotype. This timely book provides a comprehensive and contemporary analysis of morphogenetic processes in vertebrate and invertebrate embryos. After an introduction covering case studies and historical and technical approaches it reviews the mechanistic roles of extracellular matrices cell membranes and the cytoskeleton in morphogenesis. There is then a detailed discussion of how mesenchymal and epithelial cells cooperate to build a wide range of tissues the book ends by considering the dynamical basis of the subject. With its extensive literature review more than 500 titles this book will interest most developmental biologists and can also be used as an advanced textbook for postgraduate and final-year students. Developmental and cell biology series SERIES EDITORS Dr p. w. Barlow Long Ashton Research Station Bristol Dr D. Bray King s College London Dr p. B. Green Dept of Biology Stanford University Dr J. M. w. Slack ICRF Laboratory Oxford The aim of the series is to present relatively short critical accounts of areas of developmental and cell biology where sufficient information has accumulated to allow a considered distillation of the subject. The fine structure of the cells embryology morphology physiology genetics biochemistry and biophysics are subjects within the scope of the series. The books are intended to interest and instruct advanced undergraduates and graduate students and to make an important contribution to teaching cell and developmental biology. At the same time they should be of value to biologists who while not working directly in the area of a particular volume s subject matter wish to keep abreast of .