tailieunhanh - Macromolecular Crystallography

Multiprotein assemblies play major roles in most pathways involved in cell regulation and signaling. Weak binary interactions are transformed co-operatively into very specifi c systems, which achieve sensitivity, specifi city and temporal control. Due to the complexity and transience of these regulatory and signaling systems, a combination of in vivo, cell, biochemical, biophysical, and structural approaches is needed to investigate their structures and dynamics. Here we describe the architecture and spatial organisation of the complexes mediating Non-Homologous End Joining (NHEJ), one of the two major pathways involved in DNA double-strand break repair. Our example illustrates the experimental challenges and conceptual questions that are raised by studying such complex systems | NATO Science for Peace and Security Series - A Chemistry and Biology Macromolecular Crystallography Deciphering the structure Function and Dynamics of Biological Molecules Edited by Maria Armenia Carrondo Paola Spadon Springer This publication is supported by The NATO Science for Peace and Security Programme Macromolecular Crystallography NATO Science for Peace and Security Series This Series presents the results of scientific meetings supported under the NATO Programme Science for Peace and Security SPS . The NATO SPS Programme supports meetings in the following Key Priority areas 1 Defence Against Terrorism 2 Countering other Threats to Security and 3 NATO Partner and Mediterranean Dialogue Country Priorities. The types of meeting supported are generally Advanced Study Institutes and Advanced Research Workshops . The NATO SPS Series collects together the results of these meetings. The meetings are co-organized by scientists from NATO countries and scientists from NATO s Partner or Mediterranean Dialogue countries. The observations and recommendations made at the meetings as well as the contents of the volumes in the Series reflect those of participants and contributors only they should not necessarily be regarded as reflecting NATO views or policy Advanced Study Institutes ASI are high-level tutorial courses to convey the latest developments in a subject to an advanced-level audience Advanced Research Workshops ARW are expert meetings where an intense but informal exchange of views at the frontiers of a subject aims at identifying directions for future action Following a transformation of the programme in 2006 the Series has been re-named and re-organised. Recent volumes on topics not related to security which result from meetings supported under the programme earlier may be found in the NATO Science Series. The Series is published by IOS Press Amsterdam and Springer Dordrecht in conjunction with the NATO Emerging Security Challenges Division. Sub-Series A. .