tailieunhanh - Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism

The hypothalamic neuropeptides modulate physiological activity via G pro-tein-coupled receptors (GPCRs). Galanin-like peptide (GALP) is a 60 amino acid neuropeptide that was originally isolated from porcine hypo-thalamus using a binding assay for galanin receptors, which belong to the GPCR family. | IFEBS Journal MINIREVIEW Galanin-like peptide and the regulation of feeding behavior and energy metabolism Kanako Shiba1 Haruaki Kageyama1 Fumiko Takenoya1 2 and Seiji Shioda1 1 Department of Anatomy Showa University Schoolof Medicine Tokyo Japan 2 Department of PhysicalEducation Hoshi University Schoolof Pharmacy and PharmaceuticalScience Tokyo Japan Keywords clinical implication feeding regulation galanin GPCRs leptin mouse neuronal network obesity rat thermogenesis Correspondence S. Shioda Department of Anatomy Showa University Schoolof Medicine 1-5-8 Hatanodai Shinagawa-ku Tokyo 142- 8555 Japan Fax 81 3 3784 6815 Tel 81 3 3784 8103 E-mail shioda@ Received 14 June 2010 revised 5 September 2010 accepted 12 October 2010 doi The hypothalamic neuropeptides modulate physiological activity via G protein-coupled receptors GPCRs . Galanin-like peptide GALP is a 60 amino acid neuropeptide that was originally isolated from porcine hypothalamus using a binding assay for galanin receptors which belong to the GPCR family. GALP is mainly produced in neurons in the hypothalamic arcuate nucleus. GALP-containing neurons form neuronal networks with several other types of peptide-containing neurons and then regulate feeding behavior and energy metabolism. In rats the central injection of GALP produces a dichotomous action that involves transient hyperphasia followed by hypophasia and a reduction in body weight whereas in mice it has only one action that reduces both food intake and body weight. In the present minireview we discuss current evidence regarding the function of GALP particularly in relation to feeding and energy metabolism. We also examine the effects of GALP activity on food intake body weight and locomotor activity after intranasal infusion a clinically viable mode of delivery. We conclude that GALP may be of therapeutic value for obesity and life-style-related diseases in the near future. Introduction Neuropeptides .