tailieunhanh - Báo cáo khoa học: Organizing signal transduction through A-kinase anchoring proteins (AKAPs)

A fundamental role for protein–protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adap-ter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling path-way is organized by A-kinase anchoring proteins. | ễFEBS Journal MINIREVIEW Organizing signal transduction through A-kinase anchoring proteins AKAPs Jeremy S. Logue1 2 and John D. Scott1 1 Howard Hughes Medical institute and Department of Pharmacology University of Washington Schoolof Medicine Seattle WA USA 2 Molecular and Cellular Biology Program University of Washington Seattle WA USA Keywords AKAP cAMP enzyme complexes signal transduction Correspondence J. D. Scott Howard Hughes Medical institute and Department of Pharmacology University of Washington School of Medicine 1959 Pacific Ave NE Box 357750 Seattle WA 98195 USA Fax 1 206 616 3386 Tel 1 206 616 3340 E-mail scottjdw@ Website http scottjdw Received 14 May 2010 revised 23 July 2010 accepted 19 August 2010 doi A fundamental role for protein-protein interactions in the organization of signal transduction pathways is evident. Anchoring scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A-kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the cAMP-dependent protein kinase phosphoprotein phosphatases phosphodiesterases and other signaling effectors to optimize cellular responses to cAMP and other second messengers. Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview. Introduction Knowing how signal transduction cascades are effectively organized inside cells is key to understanding how cells communicate. Insight into how this is achieved has been forthcoming from research on anchoring and scaffolding proteins 1 . A number of protein kinases with broad substrate specificities associate with proteins that target them to precise sites inside the cell. Signaling events that are initiated by the second messenger cAMP involve the activation of discrete pools of anchored protein kinase A .