tailieunhanh - Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family

Regulation of gene expression is fundamental in all living organisms and is facilitated by transcription factors, the single largest group of proteins in humans. For cell- and stimulus-specific gene regulation, strict control of the transcription factors themselves is crucial. Heat shock factors are a family of transcription factors best known as master regulators of induced gene expression during the heat shock response. | ễFEBS Journal MINIREVIEW Regulation of the members of the mammalian heat shock factor family Johanna K. Bjork1 2 and Lea Sistonen1 2 1 Department of Biosciences Abo Akademi University Turku Finland 2 Turku Centre for Biotechnology University of Turku Finland Keywords development heat stress response microRNA post-translationalmodifications proteotoxic stress spermatogenesis transcription factor Correspondence L. Sistonen Department of Biosciences Abo Akademi University BioCity Tykistokatu 6 20520 Turku Finland Fax 358 2 333 8000 Tel 358 2 215 3311 E-mail Received 11 May 2010 revised 20 July 2010 accepted 11 August 2010 Regulation of gene expression is fundamental in all living organisms and is facilitated by transcription factors the single largest group of proteins in humans. For cell- and stimulus-specific gene regulation strict control of the transcription factors themselves is crucial. Heat shock factors are a family of transcription factors best known as master regulators of induced gene expression during the heat shock response. This evolutionary conserved cellular stress response is characterized by massive production of heat shock proteins which function as cytoprotective molecular chaperones against various proteotoxic stresses. In addition to promoting cell survival under stressful conditions heat shock factors are involved in the regulation of life span and progression of cancer and they are also important for developmental processes such as gametogenesis neurogenesis and maintenance of sensory organs. Here we review the regulatory mechanisms steering the activities of the mammalian heat shock factors 1-4. doi Introduction Heat shock factors HSFs are master transcriptional regulators activated by various proteotoxic stress stimuli. This cellular stress response which is called the heat shock response after the original discovery in Drosophila larvae exposed to elevated temperatures 1 is a .