tailieunhanh - Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans

The small leucine-rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease. They are now being rec- ognized as key signaling molecules with an expanding repertoire of molecu- lar interactions affecting not only growth factors, but also various receptors involved in controlling cell growth, morphogenesis and immunity. | MINIREVIEW Proteoglycans in health and disease novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans Renato V. lozzo1 and Liliana Schaefer2 1 Department of Pathology Anatomy and CellBiology and the Cancer CellBiology and Signaling Program KimmelCancer Center Thomas Jefferson University Philadelphia PA USA 2 Pharmazentrum Frankfurt Institut fur Allgemeine Pharmakologie und Toxikologie ZAFES Klinikum der JW Goethe-Universitat Frankfurt am Main Germany Keywords biglycan cancer decorin EGFR IGF-IR inflammation lumican Met signal transduction Toll-like receptor Correspondence R. V. lozzo Department of Pathology Anatomy and CellBiology Thomas Jefferson University 1020 Locust Street Room 249 JAH Philadelphia PA 19107 USA Fax 1 215 923 7969 Tel 1 215 503 2208 E-mail iozzo@ or L. Schaefer Pharmazentrum Frankfurt Institut fur Allgemeine Pharmakologie und Toxikologie Klinikum der JW Goethe-Universitat Frankfurt am Main Haus 74 Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany Fax 49 69 6301 83027 Tel 49 69 6301 7899 E-mail schaefer@ Received 15 April 2010 revised 10 July 2010 accepted 27 July 2010 doi The small leucine-rich proteoglycans SLRPs are involved in many aspects of mammalian biology both in health and disease. They are now being recognized as key signaling molecules with an expanding repertoire of molecular interactions affecting not only growth factors but also various receptors involved in controlling cell growth morphogenesis and immunity. The complexity of SLRP signaling and the multitude of affected signaling pathways can be reconciled with a hierarchical affinity-based interaction of various SLRPs in a cell- and tissue-specific context. Here we review this interacting network describe new relationships of the SLRPs with tyrosine kinase and Toll-like receptors and critically assess their roles in cancer and innate immunity. Introduction The small .