tailieunhanh - Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control

Accumulating evidence has contributed to a novel view in bone biology: bone remodeling, specifically osteoblast differentiation, is under the tight control of the central and peripheral nervous systems. Among other players in this neuro-osteogenic network, the neuropeptide Y (NPY) system has attracted particular attention. | REVIEW ARTICLE Neuropeptide Y and osteoblast differentiation - the balance between the neuro-osteogenic network and local control Filipa Franquinho1 2 Marcia A. Liz1 Ana F. Nunes3 Estrela Neto4 5 Meriem Lamghari4 and Monica M. Sousa1 1 Nerve Regeneration Group IBMC - Instituto de Biologia Molecular e Celular Universidade do Porto Portugal 2 Departamento de Anatomia Patologica Instituto Politecnico de Saude-Norte Paredes Portugal 3 Faculty of Pharmacy University of Lisbon Portugal 4 INEB - Instituto de Engenharia Biomedica Divisao de Biomateriais NewTherapies Group Universidade do Porto Portugal 5 Universidade do Porto Faculdade de Engenharia Portugal Keywords bone innervation leptin NPY NPY receptors osteoblasts Correspondence M. Mendes Sousa IBMC Rua Campo Alegre 823 4150-180 Porto Portugal Fax 351 22 6099157 Tel 351 22 6074900 E-mail msousa@ Website http nerve These authors contributed equally to this work Received 29 March 2010 revised 2 June 2010 accepted 12 July 2010 doi Accumulating evidence has contributed to a novel view in bone biology bone remodeling specifically osteoblast differentiation is under the tight control of the central and peripheral nervous systems. Among other players in this neuro-osteogenic network the neuropeptide Y NPY system has attracted particular attention. At the central nervous system level NPY exerts its function in bone homeostasis through the hypothalamic Y2 receptor. Locally in the bone NPY action is mediated by its Y1 receptor. Besides the presence of Y1 a complex network exists locally not only there is input of the peripheral nervous system as the bone is directly innervated by NPY-containing fibers but there is also input from non-neuronal cells including bone cells capable of NPY expression. The interaction of these distinct players to achieve a multilevel control system of bone homeostasis is still under debate. In this review we will integrate the current