tailieunhanh - GI Microbiota and Regulation of the Immune System

The gastrointestinal tract (GI tract) plays dual roles in hwnan physiology: digestion and uptake of nutrients and the more daunting task of maintaining immune homeostasis (protecting the body from potentially harmful microbes, while inducing tolerogenic responses to innocuous food, commensals and self-antigens). The unique architecture ofthe GI tract facilitates both ofthese functions; multiple levelsofinfolding results in an immense overall surface area that allows maximal nutrient absorption while housing the largest nwnber ofimmune cells in the body. This review will focus on how mucosal immune responses generated in the GI tract are organized and controlled. The gastro-intestinal associated lymphoid tissue (GALT), which is composed ofdiscrete inductive and effectors sites,. | ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Volume 635 of the Immune System Edited by Gary B. Huffnagle Mairi c. Noverr GI Microbiota and Regulation of the Immune System ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board NATHAN BACK State University of New York at Buffalo IRUN R. COHEN The Weizmann Institute of Science ABEL LAJTHA N. s. Kline Institute for Psychiatric Research JOHN D. LAMBRIS University of Pennsylvania RODOLFO PAOLETTI University of Milan Recent Volumes in this Series Volume 627 TRANSGENESIS AND THE MANAGEMENT OF VECTOR-BORNE DISEASE Edited by Serap Aksoy Volume 628 BRAIN DEVELOPMENT IN DROSOPHILA MELANOGASTER Edited by Gerhard M. Technau Volume 629 PROGRESS IN MOTOR CONTROL Edited by Dagmar Sternad Volume 630 INNOVATIVE ENDOCRINOLOGY OF CANCER Edited by Lev M. Berstein and Richard J. Santen Volume 631 BACTERIAL SIGNAL TRANSDUCTION Edited by Ryutaro Utsumi Volume 632 CURRENT TOPICS IN COMPLEMENT II Edited by John. D. Lambris Volume 633 CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY II Edited by Stephen p. Schoenberger Peter D. Katsikis and Bali Pulendran Volume 634 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN V Edited by Adam Finn Nigel Curtis and Andrew J. Pollard Volume 635 GI MICROBIOTA AND REGULATION OF THE IMMUNE SYSTEM Edited by Gary B. Huffhagle and Maili c. Noverr A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the .