tailieunhanh - Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of environmental factors

Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that affects –1% of the population. RA causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life. | MINIREVIEW Molecular aspects of rheumatoid arthritis role of environmental factors Shu Kobayashi Shigeki Momohara Naoyuki Kamatani and Hiroshi Okamoto Institute of Rheumatology Tokyo Women s MedicalUniversity Japan Keywords 2 3 7 8-tetrachlorodibenzo-p-dioxin TCDD cytokines environmental factors hormone NF-kB rheumatoid arthritis smoking weather Correspondence H. Okamoto Institute of Rheumatology Tokyo Women s MedicalUniversity 10-22 Kawada-cho Shinjuku Tokyo 162-0054 Japan Fax 81 3 5269 1726 Tel 81 3 5269 1725 E-mail hokamoto@ Received 14 March 2008 revised 1 June 2008 accepted 20 June 2008 Rheumatoid arthritis RA is a systemic chronic inflammatory disease that affects of the population. RA causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life. Although the pathogenesis of RA has not yet been fully elucidated it is considered to be a complex multifarious disease that is influenced by both genetic and environmental factors. Genetic influences that contribute to RA susceptibility have been demonstrated both in studies of twins and families as well as in genome-wide linkage scans and it is estimated that genetic factors are responsible for 50-60 of the risk of developing RA. Thus environmental factors may explain the remaining risk of developing RA. A large variety of environmental factors such as infectious agents smoking sex hormones pregnancy etc. have been extensively studied previously. Understanding of how these factors contribute to the development of RA may lead to the better understanding of pathogenesis of RA. doi Introduction Rheumatoid arthritis RA is a systemic chronic inflammatory disease that affects of the population and causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life. Although the pathogenesis of RA has not yet been fully .