tailieunhanh - Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint dis-ease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone. | MINIREVIEW Molecular aspects of rheumatoid arthritis chemokines in the joints of patients Takuji Iwamoto1 2 Hiroshi Okamoto1 Yoshiaki Toyama2 and Shigeki Momohara1 1 Institute of Rheumatology Tokyo Women s MedicalUniversity Japan 2 Department of Orthopaedic Surgery Schoolof Medicine Keio University Tokyo Japan Keywords chemokine receptors chemokines monocyte chemoattractant protein-4 MCP-4 CCL13 pulmonary and activation-regulated chemokine PARC CCL18 rheumatoid arthritis RA Correspondence H. Okamoto Institute of Rheumatology Tokyo Women s MedicalUniversity 10-22 Kawada-cho Shinjuku Tokyo 162-0054 Japan Fax 81 3 5269 1726 Tel 81 3 5269 1725 E-mail hokamoto@ Received 14 March 2008 revised 27 May 2008 accepted 27 June 2008 doi Rheumatoid arthritis RA is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints leading to proliferation of synoviocytes and destruction of cartilage and bone. In RA synovial tissue the infiltrating cells such as macrophages T cells B cells and dendritic cells play important role in the pathogenesis of RA. Migration of leukocytes into the synovium is a regulated multi-step process involving interactions between leukocytes and endothelial cells cellular adhesion molecules as well as chemokines and chemokine receptors. Chemokines are small chemoattractant cytokines which play key roles in the accumulation of inflammatory cells at the site of inflammation. It is known that synovial tissue and synovial fluid from RA patients contain increased concentrations of several chemokines such as monocyte chemoattractant protein-4 MCP-4 CCL13 pulmonary and activation-regulated chemokine PARC CCL18 monokine induced by interferon-y Mig CXCL9 stromal cell-derived factor 1 SDF-1 CXCL12 monocyte chemotactic protein 1 MCP-1 CCL2 macrophage inflammatory protein 1a .