tailieunhanh - báo cáo khoa học: " Identification of Single Nucleotide Polymorphisms and analysis of Linkage Disequilibrium in sunflower elite inbred lines using the candidate gene approach"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Identification of Single Nucleotide Polymorphisms and analysis of Linkage Disequilibrium in sunflower elite inbred lines using the candidate gene approach | BMC Plant Biology BioMed Central Research article Identification of Single Nucleotide Polymorphisms and analysis of Linkage Disequilibrium in sunflower elite inbred lines using the candidate gene approach Corina M Fusari1 Verónica V Lia1 2 H Esteban Hopp1 2 Ruth A Heinz1 2 and Norma B Paniego 1 Open Access Address Institute Nacional de Tecnología Agropecuaria INTA Institute de Biotecnología CNIA CC 25 Castelar B1712WAA Buenos Aires Argentina and 2Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires Argentina Email Corina M Fusari - cfusari@ Verónica V Lia - vlia@ H Esteban Hopp - ehopp@ Ruth A Heinz - rheinz@ Norma B Paniego - npaniego@ Corresponding author Published 23 January 2008 Received 22 October 2007 BMC Plant Biology 2008 8 7 doi 1471 -2229-8-7 Accepted 23 January 2008 This article is available from http 1471-2229 8 7 2008 Fusari et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Association analysis is a powerful tool to identify gene loci that may contribute to phenotypic variation. This includes the estimation of nucleotide diversity the assessment of linkage disequilibrium structure LD and the evaluation of selection processes. Trait mapping by allele association requires a high-density map which could be obtained by the addition of Single Nucleotide Polymorphisms SNPs and short insertion and or deletions indels to SSR and AFLP genetic maps. Nucleotide diversity analysis of randomly selected candidate regions is a promising approach for the success of association analysis and fine mapping in the sunflower genome. Moreover knowledge of the distance over